The National Science Foundation is evolving an ambitious vision of cyberinfrastructure—the integration of computing, data, networks, digitally enabled sensors, observatories, and experimental facilities. As the nation begins to realize this vision, significant new capabilities are emerging for educational simulation, visualization, and real-time data collection. Through cyberinfrastructure, students could overcome time and distance barriers to conduct sophisticated activities, customize their learning, and participate in virtual communities. Instructors could use sophisticated methods of assessment based on real-time data collection about individual student performance. In this seminar, distinguished scholar and Harvard professor Chris Dede discusses the implications of these developments for practice and policy today.