This report, based on the 2005 Summer Focus Session conducted by the EDUCAUSE Learning Initiative (ELI), discusses the importance of aligning teaching and learning to the basic principles of how people learn. It argues that the degree of interactivity featured in course content delivery has a strong impact on successful learning. Several models of interactivity are presented. The report features an overview of those institutional resources that must be considered in the establishment of interactive learning environments. It concludes with a pragmatic discussion on how supporters of these interactive learning environment efforts can "make the case" to institutional decision makers.